In this issue, da Silva Antunes et al. present the “MegaPool” approach, a powerful strategy for studying T cell responses and understanding the immune system's role in health and disease. The cover illustration showcases the extensive range of experimentally characterized peptide pools for diverse indications, from laboratory research to practical use (“bench to shelf”). This resource embodies a safe alternative to the handling of pathogens, and it is a valuable tool for assessing antigen-specific T cell responses in the contexts of vaccination, disease, and diagnostic evaluations.

Artist: Adam Abawi.