Volume 47, Issue 1 p. 8.23.1-8.23.17
UNIT

Fear Extinction in Rodents

Chun-hui Chang

Chun-hui Chang

University of Michigan, Ann Arbor, Michigan

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Ewelina Knapska

Ewelina Knapska

University of Michigan, Ann Arbor, Michigan

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Caitlin A. Orsini

Caitlin A. Orsini

University of Michigan, Ann Arbor, Michigan

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Christine A. Rabinak

Christine A. Rabinak

University of Michigan, Ann Arbor, Michigan

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Joshua M. Zimmerman

Joshua M. Zimmerman

University of Michigan, Ann Arbor, Michigan

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Stephen Maren

Stephen Maren

University of Michigan, Ann Arbor, Michigan

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First published: 01 April 2009
Citations: 39

Abstract

Pavlovian conditioning paradigms have become important model systems for understanding the neuroscience of behavior. In particular, studies of the extinction of Pavlovian fear responses are yielding important information about the neural substrates of anxiety disorders, such as phobias and post-traumatic stress disorder (PTSD) in humans. These studies are germane to understanding the neural mechanisms underlying behavioral interventions that suppress fear, including exposure therapy in anxiety disorders. This unit describes detailed behavioral protocols for examining the nature and properties of fear extinction in laboratory rodents. Curr. Protoc. Neurosci. 47:8.23.1-8.23.17. © 2009 by John Wiley & Sons, Inc.